tailieunhanh - Báo cáo khoa học: "Young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and long-term: Analysis of survival and prognostic markers"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and long-term: Analysis of survival and prognostic markers | Chan et al. World Journal of Surgical Oncology 2010 8 82 http content 8 1 82 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and longterm Analysis of survival and prognostic markers 1 3 3 2 3 3 3 c c . V. 14 .4 5 KK Chan B Dassanayake R Deen Kt vvicKraiTiarachChi SK Kumarage S Samita KI Deen Abstract Objectives This study compares clinico-pathological features in young 40 years and older patients 50 years with colorectal cancer survival in the young and the influence of pre-operative clinical and histological factors on survival. Materials and methods A twelve year prospective database of colorectal cancer was analysed. Fifty-three young patients were compared with forty seven consecutive older patients over fifty years old. An analysis of survival was undertaken in young patients using Kaplan Meier graphs non parametric methods Cox s Proportional Hazard Ratios and Weibull Hazard models. Results Young patients comprised percent of 397 with colorectal cancer. Duration of symptoms and presentation in the young was similar to older patients median range young patients 6 months 2 weeks to 2 years older patients 4 months 4 weeks to 3 years p . In both groups the majority presented without bowel obstruction young - 81 older - 94 . Cancer proximal to the splenic flexure was present more in young than in older patients. Synchronous cancers were found exclusively in the young. Mucinous tumours were seen in 16 of young and 4 of older patients p . Ninety four percent of young cancer deaths were within 20 months of operation. At median follow up of 50 months in the young overall survival was 70 and disease free survival 66 . American Joint Committee on Cancer AJCC stage 4 and use of pre-operative chemoradiation in rectal cancer was associated with poor survival in the young. Conclusion If patients who are

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