tailieunhanh - Báo cáo khoa học: "Early results on the use of biomaterials as adjuvant to abdominal wall closure following cytoreduction and hyperthermic intraperitoneal chemotherapy"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Early results on the use of biomaterials as adjuvant to abdominal wall closure following cytoreduction and hyperthermic intraperitoneal chemotherapy | Boutros et al. World Journal of Surgical Oncology 2010 8 72 http content 8 1 72 WORLD JOURNAL OF SURGICAL ONCOLOGY TECHNICAL INNOVATIONS Open Access Early results on the use of biomaterials as adjuvant to abdominal wall closure following cytoreduction and hyperthermic intraperitoneal chemotherapy Cherif Boutros Ponandai Somasundar N Joseph Espat Abstract Background Hyperthermic chemotherapy applies thermal energy to both abdominal wall as well as the intraabdominal viscera. The combination of the hyperthemia chemotherapy and cytoreductive surgery CRS is associated with a defined risk of abdominal wall and intestinal morbidity reported to be as high as 15 respectively to date no studies have evaluated the use of biomaterial mesh as adjuvant to abdominal wall closure in this group of patients. In the present report we hypothesized that post HIPEC closure with a biomaterial can reduce abdominal wall morbidity after CRS and hyperthermic intraperitoneal chemotherapy. Materials and methods All patients treated with HIPEC in a tertiary care center over 12 months 2008-2009 period were included. Eight patients received cytoreductive surgery followed by HIPEC for 90 minutes using Mitomycin C 15 mg q 45 minutes X 2 . Abdominal wall closure was performed using Surgisis Cook Biotech. mesh in an underlay position with 3 cm fascial overlap-closure. Operative time hospital length of stay LOS as well as postoperative outcome with special attention to abdominal wall and bowel morbidity were assessed. Results Eight patients mean age ys 36-80 were treated according to the above protocol. The primary pathology was appendiceal mucinous adenocarcinoma n 3 colorectal cancer n 3 and ovarian cancer n 2 . Four patients 50 presented initially with abdominal wall morbidity including incisional ventral hernia n 3 and excessive abdominal wall metastatic implants n 1 . The mean peritoneal cancer index PCI was . Twenty eight CRS were performed CRS patient . The mean .