tailieunhanh - Báo cáo khoa học: "Primary breast lymphomas: a multicentric experience"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Primary breast lymphomas: a multicentric experience | Avenia et al. World Journal of Surgical Oncology 2010 8 53 http content 8 1 53 RESEARCH WORLD JOURNAL OF SURGICAL ONCOLOGY Open Access Primary breast lymphomas a multicentric experience Nicola Avenia1 Alessandro Sanguinetti1 Roberto Cirocchi 2 Giovanni Bistoni3 Stefano Trastulli2 Fabio DAjello1 Francesco Barberini2 Giuseppe Cavallaro4 Antonio Rulli2 Angelo Sidoni5 Giuseppe Noya2 Giorgio De Toma4 and Francesco Sciannameo2 Abstract Background The Primary Breast Lymphomas PBL represent 0 38-0 70 of all non-Hodgkin lymphomas NHL 1 72 2 of all extranodal NHL and only 0 04-0 5 of all breast cancer. Most frequent PBLs are the diffuse large B cell lymphomas in any case-reports MALT lymphomas lack or are a rare occurrence. Their incidence is growing. From 1880 first breast resection for lymphadenoid sarcoma carried out by Gross to the recent past the gold standard treatment for such diseases was surgery. At present such role has lost some of its importance and it is matter of debate. Methods Twenty-three women affected by PBL underwent surgery. Average age was 63 years range 39-83 . Seven suffered of hypothyroidism secondary to autoimmune thyroiditis. Fourteen patients underwent mastectomy nine patients received quadrantectomy average neoplasm diameter 1 85 cm range 1 1-2 6 cm . In 10 cases axillary dissection was carried out. Pathologic examination revealed 16 diffuse large B cell lymphomas and 7 MALT lymphomas. Results Seven patients in the mastectomy group had a recurrence 50 and all of them with diffuse large B cell lymphomas at stage II. Two of these had not received chemotherapy. No patient undergoing quadrantectomy had recurrence. In the mastectomy group disease free survival DFS at 5 and 10 years was 57 and 50 . Overall survival OS at 5 and 10 years was and respectively. All recurrences were systemic. DFS and OS at 5 and 10 years was 100 in the quadrantectomy group. In the patients with recurrence mortality was . For stage IE DFS and OS .