tailieunhanh - Báo cáo khoa học: "Carcinoma ex pleomorphic adenoma of soft palate with cavernous sinus invasion"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Carcinoma ex pleomorphic adenoma of soft palate with cavernous sinus invasion | Chen et al. World Journal of Surgical Oncology 2010 8 24 http content 8 1 24 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Carcinoma ex pleomorphic adenoma of soft palate with cavernous sinus invasion Hsuan-Ho Chen 1 Li-Yu Lee2 Shy-Chyi Chin3 I-How Chen1 Chun-Ta Liao1 and Shiang-Fu Huang 1 Abstract Background Carcinoma ex pleomorphic adenoma CXPA is an aggressive salivary gland malignancy and rare in minor salivary gland. A soft palate CXPA initially presenting as direct cavernous sinus CS invasion is very rare. Case Presentation A 60-year-old male had a 3-month history of a small soft palatal mass with progressing left cheek numbness proptosis and disturbed vision. Biopsy of soft palatal tumor showed pleomorphic adenoma. Magnetic resonance imaging showed a tumor involving left maxilla and extended from pterygopalatine fossa inferior orbital fissure to CS. Excision of tumor revealed CXPA. Adjuvant concomitant chemo-radiation therapy CCRT was given. The tumor recurred 5 months later in left CS which was re-treated with CCRT. The disease status was stable at 2 years after the diagnosis of CXPA. Conclusion We present this case to emphasize that patients with symptoms such as facial numbness proptosis and disturbed vision should be carefully investigated for lesions invading CS by perineural spread. Background Carcinoma ex-pleomorphic adenoma CXPA is a rare aggressive poorly understood malignancy that usually develops in a primary or recurrent pleomorphic adenoma PA 1 . The pathogenesis has not been well understood. CXPA accounts for of all salivary neoplasms and for of salivary malignancies 2 . Less than 7 of the cases occur in the palatal minor salivary glands 3 . Misdiagnosis is not uncommon because the carcinoma may represent various subtypes in the residual PA on microscopic examination 1 . Imaging study of CXPA usually presents as non-specific characteristics 4 . We describe a 60-year-old male diagnosed as a CXPA of the soft .

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