tailieunhanh - Báo cáo khoa học: Lack of stabilized microtubules as a result of the absence of major maps in CAD cells does not preclude neurite formation

In many laboratories, the requirement of microtubule-associated proteins (MAPs) and the stabilization of microtubules for the elongation of neurites has been intensively investigated, with controversial results being obtained. We have observed that the neurite microtubules of (CAD) cells, a mouse brain derived cell, are highly dynamic structures, and so we analyzed several aspects of the cytoskeleton to investigate the molecu-lar causes of this phenomenon. | Lack of stabilized microtubules as a result of the absence of major maps in CAD cells does not preclude neurite formation C. Gaston Bisig1 Maria E. Chesta1 Guillermo G. Zampar1 Silvia A. Purro1 Veronica S. Santander2 and Carlos A. Arce1 1 Centro de Investigaciones en Quimica Biologica de Cordoba CIQUIBIC UNC-CONICET Departamento de Quimica Biologica Facultad de Ciencias Quimicas Universidad Nacionalde Cordoba Argentina 2 Departamento de Biologia Molecular Facultad de Ciencias Exactas Fisico-Quimicas y Naturales Universidad Nacionalde Rio Cuarto Argentina Keywords CAD cells microtubule-associated proteins microtubule dynamics microtubules neurites Correspondence C. A. Arce Centro de Investigaciones en Quimica Biologica de Cordoba CIQUIBIC UNC-CONICET Departamento de Quimica Biologica Facultad de Ciencias Quimicas Universidad Nacional de Coi rdoba 5000-Cordoba Argentina Fax 54 0351 4334074 Tel 54 0351 000000 E-mail caecra@ Received 19 May 2009 revised 28 September 2009 accepted 2 October 2009 doi In many laboratories the requirement of microtubule-associated proteins MAPs and the stabilization of microtubules for the elongation of neurites has been intensively investigated with controversial results being obtained. We have observed that the neurite microtubules of CAD cells a mouse brain derived cell are highly dynamic structures and so we analyzed several aspects of the cytoskeleton to investigate the molecular causes of this phenomenon. Microtubules and microfilaments were present in proportions similar to those found in brain tissue and were distributed similarly to those in normal neurons in culture. Neurofilaments were also present. Analysis of tubulin isospecies originating from post-translational modifications revealed an increased amount of tyrosinated tubulin a diminished amount of the detyrosinated form and a lack of the Delta2 form. This tyrosination pattern is in agreement with .

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