tailieunhanh - Báo cáo khoa học: Mutation of epidermal growth factor receptor is associated with MIG6 expression

Controlled activation of epidermal growth factor receptor (EGFR) is sys-tematically guaranteed at the molecular level; however, aberrant activation of EGFR is frequently found in cancer. Transcription induced by EGFR activation often involves the coordinated expression of genes that positively and negatively regulate the original signaling pathway; therefore, altera-tions in EGFR kinase activity may reflect changes in gene expression asso-ciated with the pathway. | ỊFEBS Journal Mutation of epidermal growth factor receptor is associated with MIG6 expression Takeshi Nagashima1 Ryoko Ushikoshi-Nakayama1 Atsushi Suenaga2 Kaori Ide1 Noriko Yumoto1 VAchimi M o f I I A3 iố o 1 f I I Tq Izil Ji o Q Ji 11 I lz 1 QqqI i Tuĩiĩ2 I IĨk icJiĨ TariQl a3 OJ tiJ t Enn 1 Tcqi4 Yoshimi Naruo Kaoru Takahashi Yuko Saeki Makoto Taiji Hiroshi Tanaka Shih-Feng Tsai and Mariko Hatakeyama1 1 Cellular Systems Modeling Team ComputationalSystems Biology Research Group Advanced ComputationalSciences Department RIKEN Advanced Science Institute Yokohama Kanagawa Japan 2 High-Performance Molecular Simulation Team ComputationalSystems Biology Research Group Advanced ComputationalSciences Department RIKEN Advanced Science Institute Yokohama Kanagawa Japan 3 Schoolof BiomedicalScience Tokyo Medicaland DentalUniversity Tokyo Japan 4 Division of Molecular and Genomic Medicine NationalHealth Research Institutes Zhunan Miaoli Taiwan Keywords EGFR gene expression MIG6 mutation signal transduction Correspondence M. Hatakeyama Cellular Systems Modeling Team Computational Systems Biology Research Group Advanced Computational Sciences Department RIKEN Advanced Science Institute 1-7-22 Suehiro-cho Tsurumi-ku Yokohama Kanagawa 230-0045 Japan Fax 81 45 509 9613 Tel 81 45 509 9302 E-mail marikoh@ Database Microarray data used in the present study have been deposited in the Gene Expression Omnibus database http www. geo with accession number GSE11729 Received 10 May 2009 revised 14 July 2009 accepted 16 July 2009 doi Controlled activation of epidermal growth factor receptor EGFR is systematically guaranteed at the molecular level however aberrant activation of EGFR is frequently found in cancer. Transcription induced by EGFR activation often involves the coordinated expression of genes that positively and negatively regulate the original signaling pathway therefore alterations in EGFR kinase activity may reflect