tailieunhanh - Gynecological and obstetrical manifestations of inherited bleeding disorders in women

Patients affected by bleeding disorders present a wide spectrum of clinical symptoms that vary from a mild or moderate bleeding tendency to significant episodes. Women with inherited bleeding disorders are particularly disadvantaged since, in addition to suffering from general bleeding symptoms, they are also at risk of bleeding complications from regular haemostatic challenges during menstruation, pregnancy and childbirth. Moreover, such disorders pose important problems for affected women due to their reduced quality of life caused by limitations in activities and work, and alteration of their reproductive life. These latter problems include excessive menstrual bleeding or menorrhagia, miscarriage, bleeding complications during pregnancy and after delivery and their related complications such as acute or chronic. | Journal of Thrombosis and Haemostasis 9 Suppl. 1 236-245 DOI INVITED REVIEW Gynecological and obstetrical manifestations of inherited bleeding disorders in women F. PEYVANDI I. GARAGIOLA and M. MENEGATTI . Dipartimentale per la Diagnosi e la Terapia delle Coagulopatie A. Bianchi Bonomi Hemophilia and Thrombosis Center Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico Universita degli Studi di Milano Luigi Villa Foundation Milan Italy To cite this article Peyvandi F Garagiola I Menegatti M. Gynecological and obstetrical manifestations of inherited bleeding disorders in women. J Thromb Haemost 2011 9 Suppl. 1 236-245. Summary. Patients affected by bleeding disorders present a wide spectrum of clinical symptoms that vary from a mild or moderate bleeding tendency to significant episodes. Women with inherited bleeding disorders are particularly disadvantaged since in addition to suffering from general bleeding symptoms they are also at risk of bleeding complications from regular haemostatic challenges during menstruation pregnancy and childbirth. Moreover such disorders pose important problems for affected women due to their reduced quality of life caused by limitations in activities and work and alteration of their reproductive life. These latter problems include excessive menstrual bleeding or menorrhagia miscarriage bleeding complications during pregnancy and after delivery and their related complications such as acute or chronic anaemia. The management of these women is difficult because of considerable inter-individual variation. Moreover reliable information on clinical management is scarce only a few available long term prospective studies of large cohorts provide evidence-based guideline about diagnosis and treatment. Keywords haemophilia management platelet disorders rare bleeding disorders von Willebrand disease women. Introduction Women are more likely to manifest a bleeding disorder as they have more opportunities

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