tailieunhanh - Báo cáo y học: "Cytokines in systemic lupus erythematosus, London, UK"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Cytokines in systemic lupus erythematosus, London, UK. | Arthritis Research Therapy Vol 5 No 4 Rahman Meeting report Cytokines in systemic lupus erythematosus London UK Anisur Rahman Centre for Rheumatology Department of Medicine University College London London UK Corresponding author Anisur Rahman e-mail Received 10 Mar 2003 Revisions requested 28 Mar 2003 Revisions received 8 Apr 2003 Accepted 10 Apr 2003 Published 30 Apr 2003 Arthritis Res Ther 2003 5 160-164 DOI ar767 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract The meeting consisted of 11 talks that illustrated the complexity of the pathogenetic mechanisms underlying systemic lupus erythematosus and aimed to identify ways in which cytokine modulation might affect those mechanisms. The evidence relating to the involvement of tumour necrosis factor-a interleukin-10 and BLyS in this disease was discussed in particular detail. A final discussion explored the possible ways in which cytokine modulation might lead to new methods of treating systemic lupus erythematosus in the future. Keywords cytokine systemic lupus erythematosus Introduction The aim of the meeting was to provide an overview of the ways in which modulation of cytokines may be important in the pathogenesis and treatment of systemic lupus erythematosus SLE . It comprised a set of 11 talks from an international group of speakers followed by a vigorous discussion. Marc Feldmann Kennedy Institute of Rheumatology London UK and David Isenberg University College London UK welcomed the 50 participants emphasizing the diversity clinical and serological of SLE and the likely complexity of cytokine involvement in its development. Two major themes emerged from the meeting. First lupus is a complex disease and many different elements contribute to its pathogenesis. These include factors that are intrinsic to the immune system such as B or T lymphocyte dysfunction and factors that are extrinsic to the immune system but linked to it such as abnormal clearance