tailieunhanh - Blood Disorders in the Elderly - part 10

so với tỷ lệ của nó trong một số nhóm bệnh nhân kiểm soát (cũ điều khiển 66 8 năm tuổi, điều khiển 46 14 năm tuổi trẻ) [46]. Tỷ lệ tương tự ở những người lớn tuổi có hoặc không có đột quỵ và thấp hơn ở những người già hơn so với những người trẻ. Trong kết luận | 438 Daniela Mari compared with its prevalence in several control patient groups older controls 66 8 years old young controls 46 14 years old 46 . The prevalence was the same in older individuals with or without stroke and was lower in elderly individuals than in the younger ones. In conclusion FV Leiden does not appear to influence the risk of arterial thrombosis in the elderly. Factor VIII von Willebrand factor FVIII VWF It is well known that increased plasma levels of FVIII are associated with an increased risk of venous thrombosis 47 . The plasma FVIII levels are modulated by VWF antigen VWF Ag the carrier molecule of FVIII in plasma 48 49 and ABO blood group 50 . In the CHS FVIII concentrations showed a positive association with risk of coronary heart disease among men and risk of cerebrovascular disease . transient ischemic attacks and stroke among women 51 . VWF has been identified as a risk factor for recurrent myocardial infarction in the general population and is associated with cerebrovascular disease 5254 . In the Rotterdam study 55 a strong correlation was demonstrated in elderly individuals mean age 78 between VWF and atrial fibrillation myocardial infarction diabetes and smoking in a large community-based study. Seemingly VWF concentrations were a marker of endothelial damage 55 . Recently the results of a 20-year follow-up examination ofall surviving men aged 60-79 years enrolled in the British Regional Heart Study were published 56 . In this prospective study of cardiovascular diseases non-diabetic older men with no history of cardiovascular heart disease or stroke showed a significant association between insulin resistance and inflammatory markers C-reactive protein and white cell count coagulation factors VII-IX markers of endothelial dysfunction VWF and tissue-plasminogen activator and blood viscosity. These relationships were independent of age smoking physical activity alcohol intake social class use of statin and aspirin and persisted after