tailieunhanh - báo cáo khoa học: "A Metachronous splenic metastases from esophageal cancer: a case reportr"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A Metachronous splenic metastases from esophageal cancer: a case report | Botrugno et al. World Journal of Surgical Oncology 2011 9 105 http content 9 1 105 5 2 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access A Metachronous splenic metastases from esophageal cancer a case report 1 1 1 2 3 3 Ivan Botrugno Vassili Jemos Lorenzo Cobianchi Giacomo Fiandrino Silvia Brugnatelli Vittorio Perfetti Alessandro Vercelli4 Marcello Maestri1 and Paolo Dionigi1 Abstract The spleen is an infrequent site for metastatic lesions and solitary splenic metastases from squamous cell carcinoma of the esophagus are very rare only 4 cases have been reported thus far. These lesions are whitish nodules that are macroscopically and radiologically similar to primary splenic lymphomas. We report a case of metachronous splenic metastases from esophageal cancer and multiple splenic abscesses which developed nine months after apparently curative esophagectomy without adjuvant chemotherapy. The patient underwent splenectomy dissection followed by adjuvant chemotherapy but liver and skin metastases developed and the patient died 9 months later. Keywords splenic metastases esophageal cancer splenic abscesses Background Splenic metastases from solid malignancies generally occur within a setting of extensive multiorgan involvement. Over half of all patients with metastatic disease involving five or more organs have lesions in the spleen often microscopic and these patients represent 2-7 of those who die from end-stage metastatic disease 1 2 . It is much less common to find the spleen as the sole site of metastatic spread. In cases that have been reported the splenic metastases were synchronous or metachronous lesions with patterns ranging from micro-or macronodular to diffuse infiltration of both the white and red pulp 3 4 . It is unclear why early splenic metastases are so uncommon but several of the organ s features are suspected to contribute to their rarity. They include mechanical factors such as the continuous nature of splenic blood flow the .