tailieunhanh - báo cáo khoa học: "Hepatoid adenocarcinoma of the gallbladder"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Hepatoid adenocarcinoma of the gallbladder | Ellouze et al. World Journal of Surgical Oncology 2011 9 103 http content 9 1 103 5 2 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Hepatoid adenocarcinoma of the gallbladder 1 1 2 131 1 Sameh Ellouze Charfi Slim Guirat Ahmad Gouiaa Naourez Amouri Ali Mnif Héla Kossentini Mariem Ben Amar Mohamed2 and Boudawara Tahia1 Abstract Hepatoid adenocarcinoma is a rare variant of extrahepatic adenocarcinoma which behaves like hepatocellular carcinoma in morphology and functionality. We present a rare case of hepatoid adenocarcinoma of the gallbladder which invades deeply the liver bed in a 59-year-old woman. Histologically most of the mass in the gallbladder was composed of cells with eosinophilic cytoplasm arranged in a trabecular pattern which resembled hepatocellular carcinoma. The main differential diagnosis was hepatocellular carcinoma with invasion into the gallbladder. The gallbladder origin of the hepatoid adenocarcinoma was verified by the presence of foci of conventional adenocarcinoma the recognition of highgrade dysplasia in the adjacent epithelium and the absence of cirrhosis. Keywords Hepatoid adenocarcinoma gallbladder histopathology liver hepathocellular carcinoma Background Hepatoid adenocarcinoma HAC is a variety of adenocarcinoma associated with hepatic differentiation. The most frequent site of this carcinoma is the stomach. Only a few cases of HAC of the gallbladder have been reported 1 . We present a rare case of HAC of the gallbladder which to the best of our knowledge represents the eighth reported case in the English literature. Case report A 59-year-old woman presented with abdominal pain and complains about general fatigue. Ultrasonography and computed tomography revealed a solid mass within the gallbladder which infiltrates the adjacent liver without signs of cirrhosis Figure 1a b . Laboratory data was within normal limits. The levels of serum AFP were not assessed preoperatively. Serological tests for hepatitis B virus .

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