tailieunhanh - Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: mechanism and therapeutic intervention in brain tumors

Formation of new blood vessels is required for the growth and metastasis of all solid tumors. New blood vessels are established in tumors mainly through angiogenesis. Brain tumors in particular are highly angiogenic. Therefore, interventions designed to prevent angiogenesis may be effective at controlling brain tumors. | ỊFEBS Journal MINIREVIEW Brain angiogenesis in developmental and pathological processes mechanism and therapeutic intervention in brain tumors Woo-Young Kim and Ho-Young Lee Department of Thoracic Head and Neck MedicalOncology The University of Texas M. D. Anderson Cancer Center Houston TX USA Keywords antiangiogenic therapy avarstin BBB brain tumor angiogenesis clinical trial GBM resistance VEGF vessel normalization Correspondence . Lee Department of Thoracic Head and Neck MedicalOncology Unit 432 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA Fax 1 713 792 0430 Tel 1 713 745 0769 E-mail hlee@ Received 19 February 2009 revised 14 May 2009 accepted 23 June 2009 Formation of new blood vessels is required for the growth and metastasis of all solid tumors. New blood vessels are established in tumors mainly through angiogenesis. Brain tumors in particular are highly angiogenic. Therefore interventions designed to prevent angiogenesis may be effective at controlling brain tumors. Indeed many recent findings from preclinical and clinical studies of antiangiogenic therapy for brain tumors have shown that it is a promising approach to managing this deadly disease especially when combined with other cytotoxic treatments. In this minireview we summarize the basic characteristics of brain tumor angiogenesis and the role of known angiogenic factors in regulating this angiogenesis which may be targets of antiangiogenic therapy. We also discuss the current status of antiangiogenic therapy for brain tumors the suggested mechanisms of this therapy and the limitations of this strategy. doi Introduction Brain tumors are much rarer than tumors of other organs. Specifically fewer than 2 of all tumors diagnosed each year are primary brain tumors 1 . Furthermore because of the location and other physiological characteristics of brain tumors their prognosis is very poor 1 . Whereas .