tailieunhanh - Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface

The vascular network of the brain is formed by the invasion of vascular sprouts from the pia mater toward the ventricles. Following angiogenesis of the primary vascular network, brain vessels experience a maturation pro-cess known as barriergenesis, in which the blood–brain barrier is formed. | MINIREVIEW Brain angiogenesis in developmental and pathological processes regulation molecular and cellular communication at the neurovascular interface Hye Shin Lee1 2 Jiyeon Han1 2 Hyun-Jeong Bai1 2 and Kyu-Won Kim1 2 3 1 Neurovascular Coordination Research Center College of Pharmacy SeoulNationalUniversity Korea 2 Research Institute of PharmaceuticalScience SeoulNationalUniversity Korea 3 Department of Molecular Medicine and BiopharmaceuticalSciences SeoulNationalUniversity Korea Keywords astrocyte barriergenesis blood-brain barrier brain angiogenesis endothelial cell neuron neurovascular interface pericyte perivascular macrophage smooth muscle cell Correspondence . Kim Neurovascular Coordination Research Center College of Pharmacy SeoulNationalUniversity Seoul151-742 Korea Fax 82 2 885 1827 Tel 82 2 880 6988 E-mail qwonkim@ Received 19 February 2009 revised 6 May 2009 accepted 10 June 2009 doi The vascular network of the brain is formed by the invasion of vascular sprouts from the pia mater toward the ventricles. Following angiogenesis of the primary vascular network brain vessels experience a maturation process known as barriergenesis in which the blood-brain barrier is formed. In this minireview we discuss the processes of brain angiogenesis and barriergenesis as well as the molecular and cellular mechanisms underlying brain vessel formation. At the molecular level angiogenesis and barriergenesis occur via the coordinated action of oxygen-responsive molecules . hypoxia-inducible factor and Src-suppressed C kinase substrate AKAP12 and soluble factors . vascular endothelial growth factor and angiopoie-tin-1 as well as axon guidance molecules and neurotrophic factors. At the cellular level we focus on neurovascular cells such as pericytes astrocytes vascular smooth muscle cells neurons and brain macrophages. Each cell type plays a unique role and works with other types to maintain environmental .

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