tailieunhanh - Desk Reference for hematology - part 2

Thiếu máu rối loạn mãn tính Tăng bạch cầu tỷ lệ hồng cầu lắng, đặc biệt là xạ trị đã được quản lý để điều trị cho các khu vực lumbosacral trong quá khứ, xương tủy hypoplasia sẽ vẫn còn, với những thay đổi rộng lớn nhiễm sắc thể tế bào như một hệ quả mà nguy cơ bệnh bạch cầu là mười lần lớn hơn | ANTHRACYCLINES 73 infiltration of the joints by lymphocytes and plasma cells with local bone erosion at the attachments of intervertebral and other ligaments. Other hematological disorders include Anemia of chronic disorders Elevated erythrocyte sedimentation rate Leukemia particularly if radiotherapy has been administered for treatment to the lumbosacral region in the past local bone marrow hypoplasia will remain with extensive chromosomal changes to cells as a consequence of which the risk of leukemia is ten times greater than that of the normal population Routine treatment has been nonsteroidal anti-inflammatory drugs NSAIDS and physiotherapy. Anti-tumor necrosis factor -a blocking agents infliximab adalimumab and etanercept are under ANKYRIN A protein constituent of red blood cell membranes Band that links spectrin to Band 3 protein. Rare deficiency results in heat-sensitive fragmentation hemolytic anemia. ANTENATAL SCREENING See Hemolytic disease of the newborn Transfusion-transmitted infections. ANTHRACYCLINES See also Cytotoxic agents. Cytotoxic antibiotics A group of drugs used for cytotoxic therapy that are natural products of the soil bacterium Streptomyces spp. and probably inhibit DNA replication by intercalation. They are cell-cycle-phase nonspecific agents that are given intravenously usually in pulses. They are metabolized in the liver and excreted in bile so that patients with poor liver function should receive reduced doses. The anthracyclines most often used in the treatment of acute myeloid leukemia AML are daunorubicin doxorubicin Adri-amycin idarubicin and bleomycin. They are also used as part of cytotoxic regimes in the treatment of myelomatosis and non-Hodgkin lymphoma especially diffuse large B-cell lymphoma treated with R-CHOP and Hodgkin lymphoma with ABVD. Many anthracy-clines act as radiomimetics and so should be avoided when radiotherapy is also used. Cardiotoxicity is a major cumulative dose-limiting toxicity occurring .