tailieunhanh - Báo cáo khoa học: Functional interplay between viral and cellular SR proteins in control of post-transcriptional gene regulation

Viruses take advantage of cellular machineries to facilitate their gene expression in the host. SR proteins, a superfamily of cellular precursor mRNA splicing factors, contain a domain consisting of repetitive argi-nine⁄serine dipeptides, termed the RS domain. | ỊFEBS Journal REVIEW ARTICLE Functional interplay between viral and cellular SR proteins in control of post-transcriptional gene regulation Ming-Chih Lai1 z Tsui-Yi Peng1 2 and Woan-Yuh Tarn1 1 Institute of BiomedicalSciences Academia Sinica Taipei Taiwan 2 Institute of Molecular Medicine NationalTsing Hua University Hsin-Chu Taiwan Keywords Alternative splicing kinases phosphatases phosphorylation post-transcriptionalcontrol pre-mRNA splicing RS domain SR proteins viral problems virus Correspondence . Tarn Institute of Biomedical Sciences Academia Sinica 128 Academy Road Section 2 Nankang Taipei 11529 Taiwan Fax 886 2 2782 9142 Tel 886 2 2652 3052 E-mail wtarn@ These authors contributed equally to this work Viruses take advantage of cellular machineries to facilitate their gene expression in the host. SR proteins a superfamily of cellular precursor mRNA splicing factors contain a domain consisting of repetitive argi-nine serine dipeptides termed the RS domain. The authentic RS domain or variants can also be found in some virus-encoded proteins. Viral proteins may act through their own RS domain or through interaction with cellular SR proteins to facilitate viral gene expression. Numerous lines of evidence indicate that cellular SR proteins are important for regulation of viral RNA splicing and participate in other steps of post-transcriptional viral gene expression control. Moreover viral infection may alter the expression levels or modify the phosphorylation status of cellular SR proteins and thus perturb cellular precursor mRNA splicing. We review our current understanding of the interplay between virus and host in post-transcriptional regulation of gene expression via RS domain-containing proteins. Received 3 November 2008 revised 14 December 2008 accepted 9 January 2009 doi Introduction Arginine serine RS dipeptide repeats are present in a number of cellular proteins termed SR proteins that primarily .