tailieunhanh - báo cáo khoa học: "Case report of rapidly progressive proliferative verrucous leukoplakia and a proposal for aetiology in mainland China"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Case report of rapidly progressive proliferative verrucous leukoplakia and a proposal for aetiology in mainland China | Ge et al. World Journal of Surgical Oncology 2011 9 26 http content 9 1 26 5 2 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Case report of rapidly progressive proliferative verrucous leukoplakia and a proposal for aetiology in mainland China 1 f 1 f 2 1 w 1 w 7 3 3 3 Lin Ge Yun Wu Lan-yan Wu Lin Zhang Bing Xie Xin Zeng Mei Lin Hong-mei Zhou Abstract Proliferative verrucous leukoplakia PVL is a rare oral leukoplakia and has four features such as chronic proliferation multiple occurrences refractoriness to treatment and high rate of malignant transformation. As mentioned above most PVL cases processed to malignancy over many years sometimes 20 years. However this report described a case of rapid progress which had malignant transformation in a short period. Additionally the aetiology of PVL was discussed and immunity was proposed as the possible cause. Introduction Proliferative verrucous leukoplakia PVL is a rare oral leukoplakia principally characterized by chronic proliferation multiple occurrences and refractoriness to treatment. Its rate of malignant transformation is extremely high 1 . The characteristics of its clinical and pathological progress are considered vital bases for the diagnosis of PVL because there are no particular differences between the pathological changes of PVL and those of oral verrucous leukoplakia OVL 2 . PVL grows slowly and can take up to years to become cancerous. The process is irreversible and usually progresses to cancer. According to the study by Bagan PVL quickly becomes malignant on average within years 3 whereas Hansen reported an average time to cancer of years 1 . However Silverman and Gorsky reported a longer mean malignant process of years 4 . Recently our department treated a patient with PVL that developed extremely rapidly with only 16 months from the appearance of white patches to their cancerous transformation. Consequently this case warrants attention. We describe this case .