tailieunhanh - Báo cáo khoa học: Protein transport in organelles: Dual targeting of proteins to mitochondria and chloroplasts

As many as fifty proteins have now been experimentally demonstrated to be targeted to both mitochondria and plastids, a phenomenon referred to as dual targeting. Although the first reported case of dual targeting of a protein was reported in 1995, there is still little understanding of the mech-anism of dual targeting and any similarities or differences with respect to the targeting of location-specific proteins. | ỊFEBS Journal MINIREVIEW Protein transport in organelles Dual targeting of proteins to mitochondria and chloroplasts Chris Carrie Estelle Giraud and James Whelan Australian Research CouncilCentre of Excellence in Plant Energy Biology M316 University of Western Australia Crawley Australia Keywords chloroplast dual targeting inter-organelle communication mature protein mitochondria processing receptor regulation sorting targeting signal Correspondence J. Whelan Australian Research Council Centre of Excellence in Plant Energy Biology University of Western Australia 35 Stirling Highway Crawley 6009 Australia Fax 61 8 6488 4401 Tel 61 8 6488 1749 E-mail seamus@ Website http . Received 13 August 2008 revised 19 November 2008 accepted 27 November 2008 doi As many as fifty proteins have now been experimentally demonstrated to be targeted to both mitochondria and plastids a phenomenon referred to as dual targeting. Although the first reported case of dual targeting of a protein was reported in 1995 there is still little understanding of the mechanism of dual targeting and any similarities or differences with respect to the targeting of location-specific proteins. This minireview summarizes dual targeting in terms of signals passenger proteins receptors regulation why proteins may need to be dual targeted and the future challenges that remain in this area. The traditional dogma of both cell and molecular biology one gene fi one protein fi one location has well passed its use-by date in postgenomic biology. It is clear from the sequencing of several genomes that the complexity of the proteome exceeds that of the genome in terms of the number of functional units . there are more proteins than genes . This protein complexity is achieved by a number of means of which alternative splicing of genes and protein modification are the best characterized to date 1-3 . Another mechanism to increase the .

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