tailieunhanh - báo cáo khoa học: "Pathogenesis, diagnosis and management of primary melanoma of the colon"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Pathogenesis, diagnosis and management of primary melanoma of the colon | Khalid et al. World Journal of Surgical Oncology 2011 9 14 http content 9 1 14 5 t WORLD JOURNAL OF SURGICAL ONCOLOGY REVIEW Open Access Pathogenesis diagnosis and management of primary melanoma of the colon Umair Khalid1 Taimur Saleem1 Ayesha Mallick Imam1 Muhammad Rizwan Khan2 Abstract Background Melanomas within the alimentary tract are usually metastatic in origin. On the other hand primary melanomas of the gastrointestinal tract are relatively uncommon. There are several published reports of melanomas occurring in the esophagus stomach small bowel and anorectum. The occurrence of primary melanoma of the colon has however only been rarely reported. The optimum modus operandi for the management of primary colonic melanoma remains nebulous due to the limited number of reports in literature. Methods A comprehensive search of Medline Cochrane and Highwire was performed using the following keywords melanoma malignant melanoma primary melanoma colon gastrointestinal tract alimentary tract digestive tract and large bowel . All patients with primary melanoma localized to the colon were included in the review. Patients with metastatic melanomas to the gastrointestinal GI tract and primary melanomas localized to the GI tract in anatomic locations other than colon were excluded. Results There have been only 12 reported cases of primary melanoma of the colon to date. The average age of patients on presentation was years without any significant gender predilection. Right colon 33 and cecum 33 were the most common sites for the occurrence of primary colonic melanoma while abdominal pain 58 and weight loss 50 were the most common presenting complaints. Colonoscopy is the most reliable diagnostic investigation and offers the additional advantage of obtaining tissue for diagnosis. S-100 and HMB-45 are highly sensitive and specific for the diagnosis of this malignancy. For primary colonic melanomas that have not metastasized to any distant parts of the body .