tailieunhanh - báo cáo khoa học: "Nulliparity enhances the risk of second primary malignancy of the breast in a cohort of women treated for thyroid cancer"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Nulliparity enhances the risk of second primary malignancy of the breast in a cohort of women treated for thyroid cancer | Consorti et al. World Journal of Surgical Oncology 2011 9 88 http content 9 1 88 5 t WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Nulliparity enhances the risk of second primary malignancy of the breast in a cohort of women treated for thyroid cancer Fabrizio Consorti 1 Gianluca Di Tanna2 Francesca Milazzo1 and Alfredo Antonaci1 Abstract Background Many studies have reported an increased risk of developing a second primary malignancy SPM of the breast in women treated for thyroid cancer. In this study we investigated several potential risk factors for this association. The aim of this retrospective cohort study was to identify a subgroup of women surgically treated for papillary thyroid cancer that may benefit from more careful breast cancer screening. Methods A total of 101 women surgically treated for papillary thyroid cancer from 1996 to 2009 with subsequent follow-up were interviewed by phone regarding personal risk factors and lifestyle habits. Only 75 questionnaires could be evaluated due to a rate of patients not retrieved or refusing the interview. Data analysis was performed using a multivariate logistic model. Results The standardised incidence ratio SIR for breast cancer was 95 IC - . Our data suggest a protective effect of multiparity on the development of a SPM of the breast . 95 IC - . Significant associations were not found with other known risk factors including Body Mass Index BMI age at first tumour concurrent metabolic diseases smoking physical activity and familiarity. Conclusions This study confirms that a higher incidence of SPM of the breast is observed in women treated for papillary thyroid cancer. Additionally this risk is increased by nulliparity thus a strict breast screening program for nulliparous women treated for thyroid cancer may be advisable. Keywords thyroid cancer breast cancer second primary malignancy risk factor Background Papillary thyroid cancer is the most .

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