tailieunhanh - Báo cáo y học: "Adult mesenchymal stem cells and cell-based tissue engineering"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Adult mesenchymal stem cells and cell-based tissue engineering. | Arthritis Research and Therapy Vol 5 No 1 Tuan et al. Review Adult mesenchymal stem cells and cell-based tissue engineering Rocky S Tuan Genevieve Boland and Richard Tuli Cartilage Biology and Orthopaedics Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health Bethesda Maryland USA Corresponding author Rocky S Tuan e-mail Tuanr@ Received 7 October 2002 Accepted 1 November 2002 Published 11 December 2002 Arthritis Res Ther 2003 5 32-45 DOI ar614 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract The identification of multipotential mesenchymal stem cells MSCs derived from adult human tissues including bone marrow stroma and a number of connective tissues has provided exciting prospects for cell-based tissue engineering and regeneration. This review focuses on the biology of MSCs including their differentiation potentials in vitro and in vivo and the application of MSCs in tissue engineering. Our current understanding of MSCs lags behind that of other stem cell types such as hematopoietic stem cells. Future research should aim to define the cellular and molecular fingerprints of MSCs and elucidate their endogenous role s in normal and abnormal tissue functions. Keywords cell differentiation cell signaling mesenchymal stem cells stem cells tissue engineering Introduction Despite the pluripotency of embryonic stem ES cells legal and moral controversies concerning their use for therapeutic and clinical application have prompted active examination of the reservoirs of progenitor cells harbored within the adult organism. In principle such unspecialized cells are considered to be quiescent but capable of selfrenewing their asymmetric division produces one identical daughter stem cell and a second progenitor cell that becomes committed to a lineage-specific differentiation program 1 . These cells remain in their undifferentiated state from suppression by some intrinsic or .

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