tailieunhanh - Báo cáo y học: "Acoustic stiffness and change in plug cartilage over time after autologous osteochondral grafting: correlation between ultrasound signal intensity and histological score in a rabbit model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Acoustic stiffness and change in plug cartilage over time after autologous osteochondral grafting: correlation between ultrasound signal intensity and histological score in a rabbit model. | Available online http content 6 6 R492 Research article Acoustic stiffness and change in plug cartilage over time after autologous osteochondral grafting correlation between ultrasound signal intensity and histological score in a rabbit model Hiroshi Kuroki1 Yasuaki Nakagawa2 Koji Mori3 Mao Ohba2 Takashi Suzuki2 Yasuyuki Mizuno2 Keiji Ando2 Makoto Takenaka4 Ken Ikeuchi4 and Takashi Nakamura2 Department of Physical Therapy School of Health Sciences Faculty of Medicine Kyoto University Kyoto Japan 2Department of Orthopaedic Surgery Graduate School of Medicine Kyoto University Kyoto Japan 3Applied Medical Engineering Science Graduate School of Medicine Yamaguchi University Yamaguchi Japan 4Institute for Frontier Medical Sciences Kyoto University Kyoto Japan Corresponding author Yasuaki Nakagawa ynaka@ Received 16 Mar 2004 Revisions requested 21 Apr 2004 Revisions received 11 Jun 2004 Accepted 30 Jun 2004 Published 14 Sep 2004 Arthritis Res Ther 2004 6 R492-R504 DOI ar1219 2004 Kuroki et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Open Access Abstract We investigated quantitative changes over time in ultrasound signal intensity an index of stiffness signal duration an index of surface irregularity and interval between signals an index of thickness of plug cartilage in an animal model of autologous osteochondral grafting. A full-thickness osteochondral plug was surgically removed and replaced in male Japanese white rabbits n 22 . Specimens obtained at day 0 and weeks 2 4 8 12 and 24 postoperatively were assessed using an ultrasound system and by macroscopic and histological evaluation modified Mankin s score . Histology revealed that the plug sank until 2 weeks postoperatively and that newly formed cartilagelike tissue covered the plug .