tailieunhanh - Báo cáo y học: "The relationship between predicted peptide–MHC β class II affinity and T-cell activation in a HLA-DRβ1*0401 transgenic mouse model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The relationship between predicted peptide–MHC β class II affinity and T-cell activation in a HLA-DRβ1*0401 transgenic mouse model. | Arthritis Research and Therapy Vol 5 No 1 Hill et al. Research article Open Access The relationship between predicted peptide-MHC class II affinity and T-cell activation in a HLA-DR01 0401 transgenic mouse model Jonathan A Hill1 Dequn Wang2 3 Anthony M Jevnikar1 2 4 Ewa Cairns1 2 5 6 and David A Bell1 2 5 6 1 Department of Microbiology and Immunology University of Western Ontario London Canada 2Department of Medicine University of Western Ontario London Canada 3Current address Applied Biotech Inc. San Diego California USA 4Division of Nephrology London Health Sciences Center London Ontario Canada 5Division of Rheumatology London Health Sciences Center London Ontario Canada 6EC and DAB are considered co-senior authors of this work Corresponding author David A Bell e-mail Received 27 March 2002 Revisions received 4 October 2002 Accepted 4 October 2002 Published 4 November 2002 Arthritis Res Ther 2003 5 R40-R48 DOI ar605 2003 Hill et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose provided this notice is preserved along with the article s original URL. Abstract The HLA-DRB1 0401 MHC class II molecule DR4 is genetically associated with rheumatoid arthritis. It has been proposed that this MHC class II molecule participates in disease pathogenesis by presenting arthritogenic endogenous or exogenous peptides to CD4 T cells leading to their activation and resulting in an inflammatory response within the synovium. In order to better understand DR4 restricted T cell activation we analyzed the candidate arthritogenic antigens type II collagen human aggrecan and the hepatitis B surface antigen for T-cell epitopes using a predictive model for determining peptide-DR4 affinity. We also applied this model to determine whether cross-reactive T-cell epitopes can be predicted .