tailieunhanh - Báo cáo y học: "Elucidation of the potential roles of matrix metalloproteinases in skeletal biology"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Elucidation of the potential roles of matrix metalloproteinases in skeletal biology. | Arthritis Research and Therapy Vol 5 No 1 Krane Commentary Elucidation of the potential roles of matrix metalloproteinases in skeletal biology Stephen M Krane Department of Medicine Harvard Medical School Center for Immunology and Inflammatory Diseases Massachusetts General Hospital Charlestown Massachusetts USA Corresponding author Stephen M Krane e-mail Received 4 September 2002 Accepted 6 September 2002 Published 8 October 2002 Arthritis Res Ther 2003 5 2-4 DOI ar600 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract Irreversible destruction of joint structures is a major feature of osteoarthritis and rheumatoid arthritis. Fibrillar collagens in bone cartilage and other soft tissues are critical for optimal joint form and function. Several approaches can be used to ascertain the role of collagenases matrix metalloproteinases in proteolysis of joint collagens in arthritis. These approaches include identifying spontaneous genetic disorders of the enzymes and substrates in humans and animals as well as engineering mutations in the genes that encode these proteins in mice. Insights gained from such studies can be used to design new therapies to interrupt these catabolic events. Keywords arthritis bone remodeling collagenases collagens skeletal development Introduction In a recent review in Arthritis Research Murphy et al. emphasized the importance of degradative processes in joint tissue destruction in various forms of arthritis 1 . They presented aspects of the background biochemistry of the matrix metalloproteinases MMPs as major players in the physiological turnover of the extracellular matrix and in the pathological destruction in disease. Specific inhibitors were introduced as potential therapy for arthritis based on the potential roles of MMPs even though they were directed at downstream events. Despite phenomenal advances in this area it is still necessary to establish the importance of MMPs in .