tailieunhanh - báo cáo khoa học: "Giant Merkel cell carcinoma of the eyelid: a case report and review of the literature"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Giant Merkel cell carcinoma of the eyelid: a case report and review of the literature | Chen et al. World Journal of Surgical Oncology 2011 9 58 http content 9 1 58 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Giant Merkel cell carcinoma of the eyelid a case report and review of the literature Luxia Chen1 Limin Zhu1 Jianguo Wu1 Tingting Lin1 Baocun Sun2 and Yanjin He1 Abstract Merkel cell carcinoma MCC is a rare cutaneous tumor and cases located in the eyelid have been described but still its rarity may lead to difficulty in diagnosis and delay in treatment. A 51-year-old female patient that presented with large lesions in the eyelid underwent surgery after the diagnosis of acute chalazion. Following respiratory distress secondary to pulmonary metastasis the patient s condition deteriorated and was not fit for complete excision treatment. Histopathological investigation of the biopsies taken from the tumor revealed that it was undifferentiated small cell carcinoma. Our aim with this paper is to point out that more cases should be reported for more effective diagnosis histopathological study clinical investigation treatment and prognosis of this specific neoplasm. Keywords Merkel cell carcinoma eyelid tumor diagnosis histopatholog Background Merkel cell carcinoma MCC sometimes referred to as a neuroendocrine carcinoma of the skin arises from the uncontrolled growth of Merkel cells in the skin. It was first described by Toker 1 and since then many cases have been reported. To the best of our knowledge involvement of the eyelid and face by large MCC has never been reported in the literature 2 . We here report a further case of the unusual tumor in the eyelid with histological pictorial and immunohistochemical studies which supports the hypothesis that it is derived from Merkel cells. We consider the histopathological diagnosis of mass in the eyelid to be very important. And diagnosis and treatment approaches of this entity are complex and require a skilled and experienced multidisciplinary team. Case Presentation A 51-year-old