tailieunhanh - báo cáo khoa học: "A Review of Metallothionein Isoforms and their Role in Pathophysiology"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A Review of Metallothionein Isoforms and their Role in Pathophysiology | Thirumoorthy et al. World Journal of Surgical Oncology 2011 9 54 http content 9 1 54 5 t WORLD JOURNAL OF SURGICAL ONCOLOGY REVIEW Open Access A Review of Metallothionein Isoforms and their Role in Pathophysiology NTAiri irnoorthw A CAwrarn Cl mrlar2 IAT í loniccin1 hiil ló im r3 l l QanfHil Izi im r3 f l ll Banach4 Tỉnh H iiiuihooiu iy A jnydm sunder KI Mdnisenu Hl Minidi M semi Hl Miiiidi GNK udnesn dnd Malay Chdtteijee5 Abstract The Metdllothionein MT is d protein which hds several interesting biologicdl effects dnd hds been demonstrated incredse focus on the role of MT in vdrious biologicdl systems in the pdst three decddes. The studies on the role of MT were limited with few dreds like dpoptosis dnd dntioxiddnts in selected orgdns even fifty yedrs dfter its discovery. Now dcknowledge the exploration of vdrious isoforms of MT such ds MT-I MT-II MT-III dnd MT-IV dnd other isoforms in vdrious biologicdl systems. Strong evidence exists thdt MT moduldtes complex disedses dnd the immune system in the body but the primdry function of MT still remdins unknown. This review s mdin objective is to explore the cdpdbility to specificdlly mdnipuldte MT levels in cells dnd in dnimdls to provide dnswers regdrding how MT could impdct those complex disedse scendrios. The experimentdl result mentioned in this review reldted dmong MT zinc cddmium didbetic hedrt disedse bone retdrddtion neuro toxicity kidney dysfunction cdncer dnd brdin suggest novel method for exploration dnd contribute significdntly to the growing scientist to resedrch further in this field. Keywords Metdllothionein Isoforms MT-I MT-II MT-III MT-IV Introduction The metallothionein MT was first isolated in 1957 from the cortex of horse kidney as a cadmium binding protein 1 . This protein was first reported by Kagi and Vallee in 1960 and by Kojima in 1976 as cysteine-rich 33 mol low molecular weight 7 kDa heat-stable and metal binding protein. There are at least ten known closely related .