tailieunhanh - báo cáo khoa học: "Extracranial propagation of glioblastoma with extension to pterygomaxillar fossa"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Extracranial propagation of glioblastoma with extension to pterygomaxillar fossa | Tomac et al. World Journal of Surgical Oncology 2011 9 53 http content 9 1 53 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Extracranial propagation of glioblastoma with extension to pterygomaxillar fossa P s -I- 1 1 2 3 1 I A 7 4 Damir Tomac Darko Chudy Smiljka Lambasa Iva Topic Gordan Grahovac and Arijana Zoric Abstract Background Glioblastoma multiforme is a highly malignant primary brain tumor that shows marked local aggressiveness but extracranial spread is not a common occurrence. We present an unusual case of recurrent glioblastoma in 54-year old male that spread through the scull base to the ethmoid and sphenoid sinuses to the orbita pterygomaxillar fossa and to the neck. Methods A 54-year old male underwent left temporal resection because of brain tumor of his left temporal lobe. Operation was followed by external beam radiation combined with temozolomide. The tumor recurred eight months after first surgery. The patient developed swelling of left temporal region difficult swallowing and headache. MRI of head showed recurrent tumor which invaded orbita ethmoid and sphenoid sinuses nasal cavity pterygomaxillar fossa. Results The patient died ten months after initial diagnosis of glioblastoma multiforme and two months after his second operation. Conclusions The aggressive surgical operation helped to downsize the tumor mass as much as possible but did not prolonged significantly the life or improved the life quality of the patient. The current literature is reviewed and the diagnostic approaches as well as therapeutic options are discussed. Background Glioblastoma multiforme is a highly malignant primary brain tumor. The median survival with therapy is approximately 9-12 months 1 . Glioblastoma shows marked local aggressiveness but extracranial spread is not a common occurrence. It is believed that dura provides excellent protection against infiltration by malignant tumors. Improvement of treatment options and survival time led to .