tailieunhanh - Báo cáo y học: "Perspectives and limitations of gene expression profiling in rheumatology: new molecular strategies"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Perspectives and limitations of gene expression profiling in rheumatology: new molecular strategies. | Arthritis Research Therapy Vol 6 No 4 Haupl et al. Commentary Perspectives and limitations of gene expression profiling in rheumatology new molecular strategies Thomas Haupl1 Veit Krenn2 Bruno Stuhlmuller1 Andreas Radbruch3 and Gerd R Burmester1 1 Department of Rheumatology Charité Berlin Germany institute for Pathology Charité Berlin Germany 3German Arthritis Research Centre DRFZ Berlin Germany Corresponding author Thomas Haupl Received 13 Feb 2004 Revisions requested 29 Mar 2004 Revisions received 27 Apr 2004 Accepted 12 May 2004 Published 4 Jun 2004 Arthritis Res Ther 2004 6 140-146 DOI ar1194 2004 BioMed Central Ltd Abstract The deciphering of the sequence of the human genome has raised the expectation of unravelling the specific role of each gene in physiology and pathology. High-throughput technologies for gene expression profiling provide the first practical basis for applying this information. In rheumatology with its many diseases of unknown pathogenesis and puzzling inflammatory aspects these advances appear to promise a significant advance towards the identification of leading mechanisms of pathology. Expression patterns reflect the complexity of the molecular processes and are expected to provide the molecular basis for specific diagnosis therapeutic stratification long-term monitoring and prognostic evaluation. Identification of the molecular networks will help in the discovery of appropriate drug targets and permit focusing on the most effective and least toxic compounds. Current limitations in screening technologies experimental strategies and bioinformatic interpretation will shortly be overcome by the rapid development in this field. However gene expression profiling by its nature will not provide biochemical information on functional activities of proteins and might only in part reflect underlying genetic dysfunction. Genomic and proteomic technologies will therefore be complementary in their scientific and .