tailieunhanh - Báo cáo y học: "Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross-sectional study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross-sectional study. | Available online http content 6 4 R347 Open Access Research article Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection a cross-sectional study Yoshiki Yoshihara 1 Tomoo Tsukazaki1 Makoto Osaki1 Masahiro Nakashima2 Kazuhisa Hasui3 and Hiroyuki Shindo1 Division of Orthopaedic Pathomechanism Department of Developmental and Reconstructive Medicine Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan 2Tissue and Histopathology Section Atomic Bomb Disease Institute Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan 3Department of Immunology Course of Infection and Immunity Course of Health Science Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan Corresponding author Tomoo Tsukazaki ttsuka@ Received 18 Mar 2004 Revisions requested 8 Apr 2004 Revisions received 19 Apr 2004 Accepted 7 May 2004 Published 7 Jun 2004 Arthritis Res Ther 2004 6 R347-R354 DOI ar1193 2004 Yoshihara et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Human T cell leukaemia virus type I HTLV-I is known to be involved in late-onset chronic polyarthritis as HTLV-I-associated arthropathy. However it is unclear whether HTLV-I infection could modify the pathophysiology of osteoarthritis OA . In this study we compared several inflammatory cytokines such as C-terminal parathyroid hormone-related peptide C-PTHrP soluble interleukin-2 receptor sIL-2R and interleukin IL -6 and an osteo-destruction marker deoxypyridinoline in synovial fluid SF samples obtained from 22 HTLV-I carriers and 58 control non-carrier patients with OA. These patients were diagnosed clinically and radiographically with primary OA affecting one

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