tailieunhanh - Báo cáo y học: "CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. | Available online http content 6 4 R335 Research article CD25brightCD4 regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease Duojia Cao Ronald van Vollenhoven Lars Klareskog Christina Trollmo and Vivianne Malmstrom Open Access Rheumatology Unit Department of Medicine at Karolinska Hospital Karolinska Institutet Stockholm Sweden Corresponding author Vivianne Malmstrom Received 25 Dec 2003 Revisions requested 28 Jan 2003 Revisions received 1 Apr 2004 Accepted 7 May 2004 Published 7 Jun 2004 Arthritis Res Ther 2004 6 R335-R346 DOI ar1192 2004 Cao et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract CD25 CD4 regulatory T cells participate in the regulation of immune responses. We recently demonstrated the presence of CD25brightCD4 regulatory T cells with a capacity to control T cell proliferation in the joints of patients with rheumatoid arthritis. Here we investigate a possible accumulation of these regulatory T cells in the inflamed joint of different rheumatic diseases including rheumatoid arthritis. The studies are also extended to analyze whether cytokine production can be suppressed by the regulatory T cells. Synovial fluid and peripheral blood samples were obtained during relapse from 36 patients with spondyloarthropathies 21 adults with juvenile idiopathic arthritis and 135 patients with rheumatoid arthritis and the frequency of CD25brightCD4 T cells was determined. Of 192 patients 182 demonstrated a higher frequency of CD25brightCD4 T cells in synovial fluid than in peripheral blood. In comparison with healthy subjects the patients had significantly fewer CD25brightCD4 T cells in peripheral blood. For functional studies synovial fluid cells from eight patients were sorted by

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