tailieunhanh - báo cáo khoa học: "Prognostic factors in patients with node-negative gastric cancer: an Indian experience"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Prognostic factors in patients with node-negative gastric cancer: an Indian experience | Seshadri et al. World Journal of Surgical Oncology 2011 9 48 http content 9 1 48 5 t WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Prognostic factors in patients with node-negative gastric cancer an Indian experience Ramakrishnan A Seshadri1 Sunil B Jayanand1 and Rama Ranganathan2 Abstract Background The status of the regional nodes is the most important prognostic factor in gastric cancer. There are subgroups of patients with different prognosis even in node-negative patients of gastric cancer. The aim of this study is to analyze the factors influencing the prognosis in Indian patients with node-negative gastric cancer. Methods This was a retrospective analysis of patients who underwent radical gastrectomy in a tertiary cancer centre in India between1991 and 2007. The study group included only patients with histologically node-negative disease. Various clinical pathological and treatment related factors in this group of patients were analyzed to determine their prognostic ability by univariate and multivariate analyses. Results Among the 417 patients who underwent gastrectomy during this period 122 patients had node-negative disease. A major proportion of the patients had advanced gastric cancer. The 5-year overall survival and disease-free survival in all node-negative gastric cancer patients was and respectively. The overall recurrence rate in this group was . On univariate analysis the factors found to significantly influence the disease-free survival were the size location and presence or absence of serosal invasion of the primary tumor. However on multivariate analysis only tumor size more than 3 cm and serosal invasion were found to be independently associated with an inferior survival. Conclusion Serosal invasion and primary tumor size more than 3 cm independently predict a poor outcome in patients with node-negative gastric cancer. Background The status of the regional lymph nodes is the most important prognostic .