tailieunhanh - báo cáo khoa học: "Alpha-fetoprotein-producing primary lung carcinoma: A case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Alpha-fetoprotein-producing primary lung carcinoma: A case report | Kitada et al. World Journal of Surgical Oncology 2011 9 47 http content 9 1 47 7 2 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Alpha-fetoprotein-producing primary lung carcinoma A case report 1 1 1 1 1 2 Masahiro Kitada Keisuke Ozawa Kazuhiro Sato Yoshinari Matsuda Satoshi Hayashi Yoshihiko Tokusashi Naoyuki Miyokawa2 and Tadahiro Sasajima1 Abstract Alpha-fetoprotein AFP -producing lung adenocarcinoma is a rare type of lung cancer with its characteristics not yet fully clarified. We recently encountered a case of this type of lung cancer. The patient was a 69-year-old man who consulted an internist with the chief complaint of epigastric pain. Chest X-ray and CT revealed a lobulated mass measuring 70 mm in diameter in the right lower lung field and a metastasis in the right hilar lymph nodes. Of the tumor markers the serum AFP was elevated 4620 ng ml and the serum carcinoembryonic antigen and carbohydrate antigen 19-9 were also slightly elevated. Transbronchial lung biopsy revealed the diagnosis of lung cancer. Under thoracoscopic assistance right lower lobectomy mediastinal lymph node dissection was carried out. Immunostaining showed the tumor cells to be AFP-positive. The tumor was thus diagnosed as an AFP-producing lung adenocarcinoma. The patient followed an uneventful clinical course after the surgery with serum AFP decreasing to the normal range by about 2 weeks after the surgery. As of this writing no sign of tumor recurrence has been noted. This case is presented here with a review of the literature. Background Aalpha-fetoprotein AFP is a type of protein formed in the fetal liver and yolk sac and is detected in the fetal serum. In regard to the pathological significance of this protein in adults serum AFP is often elevated in patients with liver cancer or gonadal germ cell tumors such as yolk sac tumor. Because the serum AFP level decreases in response to effective treatment measurement of the serum AFP level is carried out during