tailieunhanh - Báo cáo y học: "A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis. | Available online http content 6 4 R303 Research article A combination of autoantibodies to cyclic citrullinated peptide CCP and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis Ewa Berglin1 Leonid Padyukov2 Ulf Sundin3 Goran Hallmans4 Hans Stenlund5 Walther J van Venrooij6 Lars Klareskog2 and Solbritt Rantapaa Dahlqvist1 Department of Public Health and Clinical Medicine Division of Rheumatology University Hospital Umea Sweden 2Department of Rheumatology Karolinska Hospital Stockholm Sweden 3Department of Clinical Immunology Huddinge University Hospital Stockholm Sweden 4Department of Nutritional Research University Hospital Umea Sweden 5Department of Epidemiology University Hospital Umea Sweden 6Department of Biochemistry 161 University of Nijmegen Nijmegen The Netherlands Corresponding author Solbritt Rantapaa Dahlqvist Received 13 Jan 2004 Revisions requested 11 Feb 2004 Revisions received 2 Apr 2004 Accepted 6 Apr 2004 Published 11 May 2004 Arthritis Res Ther 2004 6 R303-R308 DOI ar1187 2004 Berglin et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Open Access Abstract Antibodies against eyelie citrullinated peptide CCP and rheumatoid factors RFs have been demonstrated to predate the onset of rheumatoid arthritis RA by years. A nested casecontrol study was performed within the Northern Sweden Health and Disease study cohort to analyse the presence of shared epitope SE genes defined as HLA-DRB 1 0404 or DRB1 0401 and of anti-CCP antibodies and RFs in individuals who subsequently developed RA. Patients with RA were identified from among blood donors whose samples had been collected years before the onset of symptoms. Controls matched for age sex and date of sampling were