tailieunhanh - Báo cáo y học: "Oxidation in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Oxidation in rheumatoid arthritis. | Available online http content 6 6 265 Review Oxidation in rheumatoid arthritis Carol A Hitchon and Hani S El-Gabalawy Arthritis Centre and Rheumatic Diseases Research Laboratory University of Manitoba Winnipeg Manitoba Canada Corresponding author Hani El-Gabalawy elgabal@ Published 13 October 2004 Arthritis Res Ther 2004 6 265-278 DOI ar1447 2004 BioMed Central Ltd Abstract Oxygen metabolism has an important role in the pathogenesis of rheumatoid arthritis. Reactive oxygen species ROS produced in the course of cellular oxidative phosphorylation and by activated phagocytic cells during oxidative bursts exceed the physiological buffering capacity and result in oxidative stress. The excessive production of ROS can damage protein lipids nucleic acids and matrix components. They also serve as important intracellular signaling molecules that amplify the synovial inflammatory-proliferative response. Repetitive cycles of hypoxia and reoxygenation associated with changes in synovial perfusion are postulated to activate hypoxia-inducible factor-1a and nuclear factor-KB two key transcription factors that are regulated by changes in cellular oxygenation and cytokine stimulation and that in turn orchestrate the expression of a spectrum of genes critical to the persistence of synovitis. An understanding of the complex interactions involved in these pathways might allow the development of novel therapeutic strategies for rheumatoid arthritis. Keywords hypoxia oxidation rheumatoid arthritis synovitis Introduction Molecular oxygen is essential for the survival of all aerobic organisms. Aerobic energy generation is dependent on oxidative phosphorylation a process by which the oxidoreduction energy of mitochondrial electron transport is converted to the high-energy phosphate bond of ATP. In this multi-step enzymatic process oxygen serves as the final electron acceptor for cytochrome c oxidase the terminal component of the mitochondrial .

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