tailieunhanh - Báo cáo y học: " Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis. | Available online http content 6 3 107 Commentary Citrullinated proteins sparks that may ignite the fire in rheumatoid arthritis Erik R Vossenaar and Walther J van Venrooij Department of Biochemistry University of Nijmegen Nijmegen The Netherlands Corresponding author Erik R Vossenaar e-mail Received 28 Jan 2004 Revisions requested 15 Mar 2004 Revisions received 5 Apr 2004 Accepted 5 Apr 2004 Published 19 Apr 2004 Arthritis Res Ther 2004 6 107-111 DOI ar1184 2004 BioMed Central Ltd Abstract Antibodies directed to citrullinated proteins . anti-CCP cyclic citrullinated peptide antibodies are highly specific for rheumatoid arthritis RA . These antibodies are produced at the site of inflammation in RA and therefore citrullinated antigens are also expected to be present in the inflamed synovium. We discuss literature showing that the presence of citrullinated proteins in the synovium is not specific for RA. The RA-specific antibodies are therefore most likely the result of an abnormal immune response that specifically occurs in RA patients. It was recently shown that presence of anti-CCP antibodies precedes the onset of clinical symptoms of RA by years. It thus appears that it may take years for initial events that cause the generation of anti-CCP antibodies to develop into full-blown disease. Keywords anti-CCP autoantibodies citrullination peptidylarginine deiminase rheumatoid arthritis Introduction Autoantibodies directed to citrullinated proteins . anti-CCP cyclic citrullinated peptide antibodies are specific serological markers for rheumatoid arthritis RA . These antibodies for review 1 are detected in approximately 80 of RA patients at a specificity of 98 2-4 . Moreover the antibodies are often present in the early stages of the disease and are predictive of disease outcome 5 6 . It was recently shown that several RA-associated genetic factors may be functionally linked to RA via modulation of the .