tailieunhanh - Báo cáo y học: "Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis. | Arthritis Research Therapy Vol 6 No 2 El-Gabalawy and Wilkins Commentary Anti-Sa antibodies prognostic and pathogenetic significance to rheumatoid arthritis Hani S El-Gabalawy and John A Wilkins Rheumatic Disease Research Laboratory University of Manitoba Winnipeg Manitoba Canada Corresponding author Hani El-Gabalawy e-mail elgabal@ Received 22 Feb 2004 Accepted 5 Mar 2004 Published 10 Mar 2004 Arthritis Res Ther 2004 6 86-89 DOI ar1171 2004 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 See related Research article http content 6 2 R142 Abstract Anti-Sa antibodies are detected in the serum of 20-47 of patients with rheumatoid arthritis. These antibodies have a high degree of specificity for the disease and appear to identify a subset of early rheumatoid arthritis patients destined to have aggressive and destructive disease. It has recently been confirmed that anti-Sa antibodies are directed to citrullinated vimentin thus placing them in the anticitrulline family of autoantibodies. The Sa antigen has previously been shown to be present in synovium. This along with the demonstration of citrullinated proteins in rheumatoid synovium suggests that anti-Sa antibodies may play a pathogenetic role in the initiation and or persistence of rheumatoid synovitis. Keywords anti-citrulline antibodies anti-Sa autoantibodies prognosis rheumatoid arthritis synovium Rheumatoid arthritis RA is characterized by the development of a persistent destructive synovitis that targets multiple joints. The joint involvement is often additive over time and there is an intriguing propensity for symmetry in the way that the joints are affected. The other characteristic feature of this disease is the presence of specific autoantibodies in the sera of most RA patients. Although this has been the strongest line of evidence suggesting that RA is an autoimmune disease it has proved to be a major challenge to understand how the synovitis and