tailieunhanh - Báo cáo y học: "Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects. | Fukami et al. Annals of General Psychiatry 2010 9 37 http content 9 1 37 ANNALS OF GENERAL PSYCHIATRY PRIMARY RESEARCH Open Access Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects 1 1 1 1 11 Goro Fukami Tasuku Hashimoto Yukihiko Shirayama Tadashi Hasegawa Hiroyuki Watanabe Mihisa Fujisaki Kenji Hashimoto2 Masaomi Iyo1 Abstract Background Benzodiazepines carry the risk of inducing cognitive impairments which may go unnoticed while profoundly disturbing social activity. Furthermore these impairments are partly associated with the elimination halflife EH of the substance from the body. The object of the present study was to examine the effects of etizolam and ethyl loflazepate with EHs of 6 h and 122 h respectively on information processing in healthy subjects. Methods Healthy people were administered etizolam and ethyl loflazepate acutely and subchronically 14 days . The auditory P300 event-related potential and the neuropsychological batteries described below were employed to assess the effects of drugs on cognition. The P300 event-related potential was recorded before and after drug treatments. The digit symbol test trail making test digit span test and verbal paired associates test were administered to examine mental slowing and memory functioning. Results Acute administration of drugs caused prolongation in P300 latency and reduction in P300 amplitude. Etizolam caused a statistically significant prolongation in P300 latency compared to ethyl loflazepate. Furthermore subchronic administration of etizolam but not ethyl loflazepate still caused a weak prolongation in P300 latency. In contrast neuropsychological tests showed no difference. Conclusions The results indicate that acute administration of ethyl loflazepate induces less effect on P300 latency than etizolam. Background Benzodiazepines have anxiolytic sedative anticonvulsant and myorelaxant properties and have been widely .