tailieunhanh - Báo cáo y học: " Induction of IL-10-producing CD4+CD25+ T cells in animal model of collagen-induced arthritis by oral administration of type II collagen"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Induction of IL-10-producing CD4+CD25+ T cells in animal model of collagen-induced arthritis by oral administration of type II collagen. | Available online http content 6 3 R213 Research article Open Access Induction of IL-10-producing CD4 CD25 T cells in animal model of collagen-induced arthritis by oral administration of type II collagen So-Youn Min1 Sue-Yun Hwang1 Kyung-Su Park2 Jae-sun Lee1 Kang-Eun Lee1 Kyung-Wun Kim1 Young-Ok Jung2 Hyunk-Jae Koh2 Ju-Ho Do2 Haerim Kim2 and Ho-Youn Kim1 2 Rheumatism Research Center Catholic Research Institute of Medical Science The Catholic University of Korea Seoul Korea 2Center for Rheumatic Disease Kangnam St. Mary s Hospital The Catholic University of Korea Medical School Seoul Korea Co-first authors order can be switched for bibliographic purposes Corresponding author Ho-Youn Kim e-mail ho@ Received 22 Oct 2003 Revisions requested 2 Dec 2003 Revisions received 10 Feb 2004 Accepted 26 Feb 2004 Published 11 Mar 2004 Arthritis Res Ther 2004 6 R213-R219 DOI ar1169 2004 Min et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Induction of oral tolerance has long been considered a promising approach to the treatment of chronic autoimmune diseases including rheumatoid arthritis RA . Oral administration of type II collagen CII has been proven to improve signs and symptoms in RA patients without troublesome toxicity. To investigate the mechanism of immune suppression mediated by orally administered antigen we examined changes in serum IgG subtypes and T-cell proliferative responses to CII and generation of IL-10-producing CD4 CD25 T-cell subsets in an animal model of collagen-induced arthritis CIA . We found that joint inflammation in CIA mice peaked at 5 weeks after primary immunization with CII which was significantly less in mice tolerized by repeated oral feeding of CII before CIA induction. Mice that had been fed with CII also .