tailieunhanh - Báo cáo y học: "Enhanced osteoclast development in collagen-induced arthritis γ in interferon-γ receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Enhanced osteoclast development in collagen-induced arthritis γ in interferon-γ receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis. | Arthritis Research Therapy Vol 6 No 3 De Klerck et al. Research article Open Access Enhanced osteoclast development in collagen-induced arthritis in interferon-y receptor knock-out mice as related to increased splenic CD11b myelopoiesis Bert De Klerck1 Isabelle Carpentier2 Rik J Lories3 Yvette Habraken4 Jacques Piette4 Geert Carmeliet5 Rudi Beyaert2 Alfons Billiau1 and Patrick Matthys1 Laboratory of Immunobiology Rega Institute Katholieke Universiteit Leuven Leuven Belgium 2Department of Molecular Biomedical Research Ghent University - VIB Ghent Belgium 3Laboratory for Skeletal Development and Joint Disorders University Hospitals Leuven Katholieke Universiteit Leuven Leuven Belgium 4Laboratory of Virology and Immunology Institute of Pathology University of Liège Liège Belgium 5Laboratory for Experimental Medicine and Endocrinology Katholieke Universiteit Leuven Leuven Belgium Corresponding author Patrick Matthys e-mail Received 12 Dec 2003 Revisions requested 9 Jan 2004 Revisions received 20 Feb 2004 Accepted 24 Feb 2004 Published 12 Mar 2004 Arthritis Res Ther 2004 6 R220-R231 DOI ar1167 2004 De Klerck et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Collagen-induced arthritis CIA in mice is accompanied by splenomegaly due to the selective expansion of immature CD11b myeloblasts. Both disease manifestations are more pronounced in interferon-y receptor knock-out IFN-yR KO mice. We have taken advantage of this difference to test the hypothesis that the expanding CD11b splenic cell population constitutes a source from which osteoclast precursors are recruited to the joint synovia. We found larger numbers of osteoclasts and more severe bone destruction in joints of IFN-yR KO mice than in joints of wild-type mice. Osteoclast-like .