tailieunhanh - Báo cáo y học: "Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis. | Available online http content 6 3 R199 Research article Open Access Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis Sylvia Dorr1 Nadine Lechtenbohmer1 Rolf Rau2 Gertraud Herborn2 Ulf Wagner3 Bertram Muller-Myhsok4 Ingo Hansmann1 and Gernot Keyszer5 Institute of Human Genetics University of Halle Saale Germany 2Evangelisches Fachkrankenhaus Ratingen Germany 3Rheumazentrum University of Leipzig Leipzig Germany 4Bernhard-Nocht-Institute Hamburg Germany 5Department of Internal Medicine I University of Halle Saale Germany Corresponding author Gernot Keyszer e-mail Received 5 Dec 2003 Revisions requested 6 Jan 2004 Revisions received 9 Feb 2004 Accepted 19 Feb 2004 Published 8 Mar 2004 Arthritis Res Ther 2004 6 R199-R207 DOI ar1164 2004 Dorr et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract The genetic background of rheumatoid arthritis RA is only partly understood and several genes seem to be involved. The matrix metalloproteinases MMP1 interstitial collagenase and MMP3 stromelysin 1 are thought to be important in destructive joint changes seen in RA. In the present study functional relevant promoter polymorphisms of MMP1 and MMP3 were genotyped in 308 patients and in 110 controls to test whether the polymorphisms contribute to the severity of the disease measured by radiographic progression of joint destruction. For comparison the shared epitope of HLA DR4 and DR1 SE was determined by polymerase chain reaction. There was no association of MMP polymorphisms with susceptibility to RA. However a strong linkage disequilibrium was observed between the 1G 2G MmPi and the 5A 6A MMP3 polymorphisms P 10-6 linkage disequilibrium index D . .