tailieunhanh - Báo cáo y học: "β Susceptibility to collagen-induced arthritis is modulated by TGFβ responsiveness of T cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: β Susceptibility to collagen-induced arthritis is modulated by TGFβ responsiveness of T cells. | Arthritis Research Therapy Vol 6 No 2 Schramm et al. Research article Open Access Susceptibility to collagen-induced arthritis is modulated by TGFp responsiveness of T cells Christoph Schramm1 Jorg Kriegsmann2 Martina Protschka3 Samuel Huber1 Torsten Hansen4 Edgar Schmitt5 Peter Robert Galle1 and Manfred Blessing2 6 1I. Medizinische Klinik Johannes Gutenberg-Universitat Mainz Mainz Germany 2Gemeinschaftspraxis fur Pathologie Trier Germany 3I. Medizinische Klinik Abteilung Pathophysiologie Johannes Gutenberg-Universitat Mainz Mainz Germany 4Institut fur Pathologie Johannes Gutenberg-Universitat Mainz Mainz Germany 5Institut fur Immunologie Mainz Germany 6Biotechnologisch-Biomedizinisches Zentrum Leipzig Germany Correspondence Christoph Schramm e-mail schramm@ Received 7 Nov 2002 Revisions requested 29 Nov 2002 Revisions received 12 Dec 2003 Accepted 17 Dec 2003 Published 8 January 2004 Arthritis Res Ther 2004 6 R114-R119 DOI ar1039 2004 Schramm et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract The objective of our study was to determine the regulatory effects that endogenous transforming growth factor p TGFP exerts on T cells in the pathogenesis of collagen-induced arthritis CIA . CIA was induced in transgenic mice expressing a dominant negative TGFp type II receptor in T cells under the control of the human CD2 promoter. Clinical and histological arthritis scores were determined and experiments on disease induction and the healing phase of disease were performed. The proliferation and cytokine production of draining lymph node cells in vitro were analyzed. Transgenic mice were more susceptible to induction of CIA. The overall incidence was higher in Keywords dominant negative TGFp type II receptor IFNy .

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