tailieunhanh - Báo cáo y học: "Natural killer cells and autoimmunity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Natural killer cells and autoimmunity. | Arthritis Research Therapy Vol 6 No 1 French and Yokoyama Review Natural killer cells and autoimmunity Anthony R French1 and Wayne M Yokoyama2 Division of Pediatric Rheumatology Department pf Pediatrics Washington University School of Medicine St Louis MO USA 2Howard Hughes Medical Institute Division of Rheumatology Department of Medicine Washington University School of Medicine St Louis MO USA Corresponding author Wayne M Yokoyama e-mail yokoyama@ Received 5 Nov 2003 Accepted 24 Nov 2003 Published 9 Dec 2003 Arthritis Res Ther 2004 6 8-14 DOI ar1034 2004 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract Autoimmune diseases are often characterized as clinical syndromes caused by the inappropriate activation of T or B cells resulting in systemic or organ-specific damage. However studies support a role for the innate immune system and in particular natural killer NK cells in stimulating or suppressing autoimmunity. This review focuses on recent research elucidating a potential immunoregulatory role for NK cells in modulating T and B cell-mediated autoimmunity. Keywords autoimmunity immunoregulation natural killer cells Natural killer cells Natural killer NK cells are large granular bone marrow-derived lymphocytes that do not express T or B cell receptors 1 . In humans these CD3-negative cells are identified by the surface markers CD16 and CD56 and comprise 5-15 of the peripheral blood mononuclear cells in normal individuals 2 . Although they were initially identified by their ability to lyse tumor cells without prior sensitization more recent work has demonstrated that they have a crucial role in the initial defense against pathogens and are particularly important in responding to viral infections reviewed in 3 4 . NK cells are poised for a rapid response to infected or transformed cells either by killing the abnormal cells or by releasing immunomodulatory chemokines and cytokines such as interferon-Y IFN-y . The chemokines .