tailieunhanh - Báo cáo y học: "Enhanced expression of interferon-inducible protein 10 associated with Th1 profiles of chemokine receptor in autoimmune pulmonary"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Enhanced expression of interferon-inducible protein 10 associated with Th1 profiles of chemokine receptor in autoimmune pulmonary. | Arthritis Research Therapy Vol 6 No 1 Shiozawa et al. Research article Open Access Enhanced expression of interferon-inducible protein 10 associated with Th1 profiles of chemokine receptor in autoimmune pulmonary inflammation of MRL Ipr mice Fumitaka Shiozawa Tsuyoshi Kasama Nobuyuki Yajima Tsuyoshi Odai Takeo Isozaki Mizuho Matsunawa Yoshiyuki Yoda Masao Negishi Hirotsugu Ide and Mitsuru Adachi Division of Rheumatology and Clinical Immunology First Department of Internal Medicine Showa University School of Medicine Tokyo Japan Corresponding author Tsuyoshi Kasama e-mail tkasama@ Received 6 Oct 2003 Revisions requested 22 Oct 2003 Revisions received 3 Nov 2003 Accepted 4 Nov 2003 Published 19 Nov 2003 Arthritis Res Ther 2004 6 R78-R86 DOI ar1029 2004 Shiozawa et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract MRL Mp-lpr lpr MRL lpr mice spontaneously develop systemic lupus erythematosus SLE -like disease. The natural history of the pulmonary involvement and the underlying mechanism of leukocyte infiltration into the lungs of MRL lpr mice and SLE patients remains elusive. We aimed to investigate the expression profiles of chemokines and chemokine receptors in the lung of the SLE-prone mouse. We examined the correlation between lung inflammation and expression of IP-10 interferon-y-inducible protein 10 a CXC chemokine and TARC thymus- and activation-regulated chemokine a CC chemokine in MRL lpr mice MRL Mp- MRL mice and C57BL 6 B6 control mice. The extent of cell infiltration in the lung was assessed histopathologically. Reverse transcriptase PCR showed up-regulation of IP-10 mRNA expression in the lungs P of MRL lpr mice in comparison with MRL or B6 mice. The increase paralleled increased expression of a