tailieunhanh - Báo cáo y học: "No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis. | Available online http content 11 1 R5 Research article No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis Olivier Jaen1 Elisabeth Petit-Teixeira2 Holger Kirsten3 Peter Ahnert3 Luca Semerano1 4 Céline Pierlot2 Francois Cornelis2 5 Marie-Christophe Boissier1 4 Geraldine Falgarone1 4 for the European Consortium on Rheumatoid Arthritis Families 1EA-4222 University of Paris 13 74 rue Marcel Cachin 9301 7 Bobigny cedex Paris France 2Genhotel EA-3886 University Evry-Paris 7 Medical School Member of the AutoCure European Consortium CP5727 91057 Evry-Genopole cedex Paris France 3University of Leipzig D-04109 Leipzig Germany 4Rheumatology Department Avicenne Hospital AP-HP 93009 Bobigny cedex Paris France 5Unité de Génétique Clinique Pôle des Laboratoires Médicaux-Imagerie-Pharmacie Lariboisière Hospital AP-HP 2 rue Ambroise Paré 75010 Paris France Corresponding author Geraldine Falgarone Received 30 May 2008 Revisions requested 18 Aug 2008 Revisions received 23 Sep 2008 Accepted 13 Jan 2009 Published 13 Jan 2009 Arthritis Research Therapy 2009 11 R5 doi 1 ar2589 This article is online at http content 11 1 R5 2009 Jaen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The objective was to study the potential genetic contribution of Toll-like receptor TLR genes in rheumatoid arthritis RA . TLRs bind to pathogen-associated molecular patterns and TLR genes influence both proinflammatory cytokine production and autoimmune responses. Hostpathogen interactions are involved in RA physiopathology. Methods We tested SNPs of five TLR genes TLR9 TLR2 TLR6 TLR1 and TLR4 in a cohort