tailieunhanh - Báo cáo y học: "α Anti-α-fodrin antibodies do not add much to the diagnosis of Sjögren’s syndrome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: α Anti-α-fodrin antibodies do not add much to the diagnosis of Sjögren’s syndrome. | Available online http content 6 1 R33 Research article Open Access Anti-a-fodrin antibodies do not add much to the diagnosis of Sjogren s syndrome Michiel M Zandbelt1 Judith Vogelzangs2 Leo BA van de Putte1 Walther J van Venrooij2 Frank HJ van den Hoogen1 1 Department of Rheumatology University Medical Center St Radboud Nijmegen The Netherlands 2Department of Biochemistry University of Nijmegen The Netherlands Correspondence Frank HJ van den Hoogen e-mail Received 9 Jun 2003 Revisions requested 21 Jul 2003 Revisions received 13 Oct 2003 Accepted 15 Oct 2003 Published 31 Oct 2003 Arthritis Res Ther 2004 6 R33-R38 DOI ar1021 2004 Zandbelt et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract The presence of anti-a-fodrin autoantibodies has been reported to be a highly specific and sensitive test for the diagnosis of Sjogren s syndrome SjS . We looked in Nijmegen for anti-a-fodrin anti-Ro60 and anti-La autoantibodies in a cohort of 51 patients with rheumatic diseases primary SjS 21 secondary SjS 6 rheumatoid arthritis RA 12 systemic lupus erythematosus SLE 6 and scleroderma 6 and in 28 healthy subjects using ELISA immunoblotting and immunoprecipitation. The same samples were analyzed with an alternative anti-a-fodrin ELISA in Hanover. The Nijmegen ELISA of the sera from primary SjS showed sensitivities of 43 and 48 for IgA- and IgG-type anti-a-fodrin antibodies respectively. The Hanover ELISA showed sensitivities of 38 and 10 for IgA- and IgG-type anti-a-fodrin antibodies respectively. The Keywords alpha-fodrin antibody ELISA sensitivity Sjogren ELISAs for a-fodrin showed six Nijmegen and four Hanover anti-a-fodrin-positive RA sera. IgA and IgG anti-fodrin antibodies were also .

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