tailieunhanh - Báo cáo y học: "κ Regulation of NFκB signalling during inflammation: the role of hydroxylases"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: κ Regulation of NFκB signalling during inflammation: the role of hydroxylases. | Available online http content 11 1 215 Review Hypoxia Regulation of NFkB signalling during inflammation the role of hydroxylases Kathryn M Oliver Cormac T Taylor and Eoin P Cummins School of Medicine and Medical Science Conway Institute University College Dublin Belfield Dublin 4 Ireland Corresponding author Eoin P Cummins Published 23 February 2009 This article is online at http content 11 1 215 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 215 doi ar2575 Abstract NFkB is a master regulator of innate immunity and inflammatory signalling. Microenvironmental hypoxia has long been identified as being coincident with chronic inflammation. The contribution of microenvironmental hypoxia to NFKB-induced inflammation has more recently been appreciated. Identification of the co-regulation of NFkB and hypoxia inducible factor HIF pathways by 2-oxo-glutarate-dependent hydroxylase family members has highlighted an intimate relationship between NFkB inflammatory signalling and HIF-mediated hypoxic signalling pathways. Adding another layer of complexity to our understanding of the role of NFkB inflammatory signalling by hypoxia is the recent recognition of the contribution of basal NFkB activity to HIF-1 a transcription. This observation implicates an important and previously unappreciated role for NFkB in inflammatory disease where HIF-1 a is activated. The present review will discuss recent literature pertaining to the regulation of NFkB inflammatory signalling by hypoxia and some of the inflammatory diseases where this may play an important role. Furthermore we will discuss the potential for prolyl-hydroxylase inhibitors in inflammatory disease. NFkB The transcription factor NFkB has been investigated for its diverse range of functions in innate immunity stress responses cell survival and development. It is also the master regulator of the inflammatory response 1 . An in-depth review of .

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