tailieunhanh - Báo cáo y học: "Neural immune pathways and their connection to inflammatory diseases"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Neural immune pathways and their connection to inflammatory diseases. | Available online http content 5 6 251 Review Neural immune pathways and their connection to inflammatory diseases Farideh Eskandari Jeanette I Webster and Esther M Sternberg Section on Neuroendocrine Immunology and Behavior NIMH NIH Bethesda MD USA Corresponding author Esther M. Sternberg e-mail ems@ Received 1 May 2003 Revisions requested 4 Jun 2003 Revisions received 8 Aug 2003 Accepted 18 Aug 2003 Published 23 Sep 2003 Arthritis Res Ther 2003 5 251-265 DOI ar1002 Abstract Inflammation and inflammatory responses are modulated by a bidirectional communication between the neuroendocrine and immune system. Many lines of research have established the numerous routes by which the immune system and the central nervous system CNS communicate. The CNS signals the immune system through hormonal pathways including the hypothalamic-pituitary-adrenal axis and the hormones of the neuroendocrine stress response and through neuronal pathways including the autonomic nervous system. The hypothalamic-pituitary-gonadal axis and sex hormones also have an important immunoregulatory role. The immune system signals the CNS through immune mediators and cytokines that can cross the blood-brain barrier or signal indirectly through the vagus nerve or second messengers. Neuroendocrine regulation of immune function is essential for survival during stress or infection and to modulate immune responses in inflammatory disease. This review discusses neuroimmune interactions and evidence for the role of such neural immune regulation of inflammation rather than a discussion of the individual inflammatory mediators in rheumatoid arthritis. Keywords cytokine hypothalamic-pituitary-adrenal axis immune inflammatory neural rheumatoid arthritis Introduction The inflammatory response is modulated in part by a bidirectional communication between the brain and the immune systems. This involves hormonal and neuronal mechanisms by which the brain regulates the .

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