tailieunhanh - Báo cáo y học: "Electrophoretic characterization of species of fibronectin bearing sequences from the N-terminal heparin-binding domain in synovial fluid samples from patients with osteoarthritis and rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Electrophoretic characterization of species of fibronectin bearing sequences from the N-terminal heparin-binding domain in synovial fluid samples from patients with osteoarthritis and rheumatoid arthritis. | Available online http content 5 6 R329 Research article Open Access Electrophoretic characterization of species of fibronectin bearing sequences from the N-terminal heparin-binding domain in synovial fluid samples from patients with osteoarthritis and rheumatoid arthritis John H Peters1 2 Steven Carsons3 Mika Yoshida4 Fred Ko4 Skye McDougall4 5 Grace A Loredo1 2 and Theodore J Hahn4 5 Department of Internal Medicine University of California Davis School of Medicine Davis CA USA 2Sacramento VA Medical Center VA Northern California Health Care System Mather CA USA 3Winthrop University Hospital Mineola NY USA 4Geriatric Research Education and Clinical Center West Los Angeles VA Medical Center VA Greater Los Angeles Healthcare System Los Angeles CA USA 5University of California Los Angeles School of Medicine Los Angeles CA USA Corresponding author John H Peters e-mail Received 2 Jan 2003 Revisions requested 3 Mar 2003 Revisions received 11 Aug 2003 Accepted 15 Aug 2003 Published 8 Sep 2003 Arthritis Res Ther 2003 5 R329-R339 DOI ar1001 2003 Peters et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Fragments of fibronectin FN corresponding to the N-terminal heparin-binding domain have been observed to promote catabolic chondrocytic gene expression and chondrolysis. We therefore characterized FN species that include sequences from this domain in samples of arthritic synovial fluid using one-and two-dimensional 1D and 2D Western blot analysis. We detected similar assortments of species ranging from 47 to greater than 200 kDa in samples obtained from patients with osteoarthritis n 9 versus rheumatoid arthritis n 10 . One of the predominant forms with an apparent molecular weight of .

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.