tailieunhanh - Báo cáo y học: " HLA class II associations with rheumatic heart disease among clinically homogeneous patients in children in Latvia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: HLA class II associations with rheumatic heart disease among clinically homogeneous patients in children in Latvia. | Arthritis Research Therapy Vol 5 No 6 Stanevicha et al. Research article Open Access HLA class II associations with rheumatic heart disease among clinically homogeneous patients in children in Latvia Valda Stanevicha1 Jelena Eglite2 Arturs Sochnevs2 Dace Gardovska1 Dace Zavadska1 and Ruta Shantere3 Department of Pediatrics Riga Stradins University Riga Latvia 2Department of Immunology Riga Stradins University Riga Latvia 3Department of Rheumatology Children s Clinical University Hospital Riga Latvia Corresponding author Valda Stanevicha e-mail Received 2 Jan 2003 Revisions requested 3 Mar 2003 Revisions received 11 Aug 2003 Accepted 15 Aug 2003 Published 8 Sep 2003 Arthritis Res Ther 2003 5 R340-R346 DOI ar1000 2003 Stanevicha et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Genetic control of immune reactions has a major role in the development of rheumatic heart disease RHD and differs between patients with rheumatic fever RF . Some authors think the risk of acquiring RHD is associated with the HLA class II DR and DQ loci but other views exist due to the various HLA-typing methods and ways of grouping cases. Our goal was to determine the relations between HLA class II alleles and risk of or protection from RF in patients with relatively homogeneous clinical manifestations. A total of 70 RF patients under the age of 18 years were surveyed in Latvia. HLA genotyping of DRB1 01 to DRB1 18 and DqB1 0201-202 0301-305 0401-402 0501-504 and 0601-608 was performed using polymerase chain reaction sequence-specific primers. Data for a control group of 100 healthy individuals typed for HLA by the same method were available from the databank of the Immunology Institute of Latvia. Of the RF patients 47 had RHD