tailieunhanh - Báo cáo y học: "Analysis of HLA DR, HLA DQ, C4A, FcγRIIa, FcγRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcγRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Analysis of HLA DR, HLA DQ, C4A, FcγRIIa, FcγRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcγRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility. | Available online http content 6 6 R557 Research article Analysis of HLA DR HLA DQ C4A FcyRIIa FcyRIIIa MBL and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcyRIIa R R and IL-1Ra 2 2 genotypes on disease susceptibility Andreas Jonsen1 Anders A Bengtsson1 Gunnar Sturfelt1 and Lennart Truedsson2 Open Access Department of Rheumatology Lund University Hospital Lund Sweden 2Department of Laboratory Medicine Section of Microbiology Immunology and Glycobiology Lund University Lund Sweden Corresponding author Lennart Truedsson Received 22 Dec 2003 Revisions requested 12 Jan 2004 Revisions received 16 Jun 2004 Accepted 16 Jul 2004 Published 23 Sep 2004 Arthritis Res Ther 2004 6 R557-R562 DOI ar1 224 2004 Jonsen et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Abstract Dysfunction in various parts of immune defence such as immune response immune complex clearance and inflammation has an impact on pathogenesis in systemic lupus erythematosus SLE . We hypothesised that combinations of common variants of genes involved in these immune functions are associated with susceptibility to SLE. The following variants were analysed HLA DR3 HLA DQ2 C4AQ0 Fcy receptor Ila FcyRlla genotype R R Fcy receptor Illa FcRyllla genotype F F mannan-binding lectin MBL genotype conferring a low serum concentration of MBL MBL-low and interleukin-1 receptor antagonist lL-1Ra genotype 2 2. Polymorphisms were analysed in 143 Caucasian patients with SLE and 200 healthy controls. HLA DR3 in SLE patients was in 90 part of the haplotype HLA DR3-DQ2-C4AQ0 which was strongly associated with SLE odds ratio OR 95 Cl . Analysis of .