tailieunhanh - Báo cáo y học: "Mactinin: a modulator of the monocyte response to inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Mactinin: a modulator of the monocyte response to inflammation. | Arthritis Research Therapy Vol 5 No 6 Luikart et al. Research article Open Access Mactinin a modulator of the monocyte response to inflammation Sharon D Luikart1 Hollis E Krug1 Robert D Nelson2 Timothy Hinkel1 Peter Majeski1 Pankaj Gupta1 Maren L Mahowald1 and Theodore Oegema3 1 Department of Medicine Veterans Affairs Medical Center and University of Minnesota Minneapolis Minnesota USA 2Ramsey Burn Center Regions Hospital St Paul Minnesota USA 3Department of Biochemistry Rush University Chicago Illinois USA Corresponding author Sharon Luikart e-mail Received 14 Apr 2003 Revisions requested 11 Jun 2003 Revisions received 8 Jul 2003 Accepted 11 Jul 2003 Published 5 Aug 2003 Arthritis Res Ther 2003 5 R310-R316 DOI ar799 This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract During inflammatory processes monocytes leave the blood stream at increased rates and enter inflammation tissue where they undergo phenotypic transformation to mature macrophages with enhanced phagocytic activity. a-Actinin a cytoskeletal protein is present in focal adhesion complexes and left in the microenvironment as a result of cell movement. Mactinin a 31 kDa amino-terminal fragment of a-actinin is generated by the degradation of extracellular a-actinin by monocyte-secreted urokinase. We have previously demonstrated that mactinin promotes monocyte macrophage maturation. We now report that mactinin has significant chemotactic activity for monocytes. Mactinin seems to be present in inflammatory arthritis synovial fluid because affinity-purified antisera reacted with a protein of the expected molecular mass in various types of arthritis fluids that were immunoaffinity-purified and subjected to Western analysis. Thus six of seven samples from patients with psoriatic arthritis reactive arthritis gout or .